TABLE 1.
Clinical Characteristics of the Autopsy-Negative SUD Cohorta
| Characteristic | All cases | LQTS-positive cases | CPVT1-positive cases | Negative cases |
|---|---|---|---|---|
| No. of individuals | 173 | 25 | 20 | 128 |
| Sex, No. | ||||
| Male | 106 | 8 | 11 | 87 |
| Female | 67 | 17 | 9 | 41 |
| Age at SUD (y), mean ± SD (range) | ||||
| Overall | 18.4±12.9 (1-69) | 17.6±9.4 (2-43) | 16.5±10.2 (2-36) | 18.9±13.9 (1-69) |
| Females | 18.8±13 (1-52) | 18.11±10.4 (4-43) | 18.9±11 (5-35) | 19.3±14 (1-52) |
| Males | 18.2±13 (1-69) | 16.6±7.2 (3-24) | 14.5±9.6 (2-36) | 18.8±14 (1-69) |
| Reported ethnicity, No. | ||||
| White | 154 | 24 | 16 | 113 |
| Black | 9 | 1 | 3 | 6 |
| Hispanic | 6 | 0 | 1 | 5 |
| Asian | 3 | 0 | 0 | 3 |
| Unknown | 1 | 0 | 0 | 1 |
| Events at SUD | ||||
| Sleep | 70 (40.5) | 12 (48.0) | 1 (5.0) | 57 (44.5) |
| Nonspecific | 52 (30.1) | 6 (24.0) | 8 (40.0) | 38 (29.7) |
| Exertion | 46 (26.6) | 5 (20.0) | 11 (55.0) | 30 (23.4) |
| Auditory | 1 (0.6) | 1 (4.0) | 0 | 0 |
| Emotion | 4 (2.3) | 1 (4.0) | 0 | 3 (2.3) |
| Personal history before SUD | ||||
| Positive | 42 (24.3) | 8 (32.0) | 7 (35.0) | 27 (21.1) |
| Negative | 124 (71.7) | 15 (60.0) | 13 (65.0) | 96 (75.0) |
| Unknown | 7 (4.0) | 2 (8.0) | 0 | 5 (3.9) |
| Family history of cardiac events | ||||
| Positive | 34 (19.7) | 5 (20.0) | 7 (35.0) | 22 (17.2) |
| Negative | 127 (73.4) | 19 (76.0) | 12 (60.0) | 96 (75.0) |
| Unknown | 12 (6.9) | 1 (4.0) | 1 (5.0) | 10 (7.8) |
| Family history of SCD | 20 (11.5) | 2 (8.0) | 7 (35.0) | 11 (8.6) |
| Personal or family history | ||||
| Seizures | 12 (6.9) | 1 (4.0) | 2 (10.0) | 9 (7.0) |
| Syncope | 25 (14.5) | 9 (36.0) | 4 (20.0) | 12 (9.4) |
CPVT1 = catecholaminergic polymorphic ventricular tachycardia type 1; LQTS = long QT syndrome; SUD = sudden unexplained death.
a
Data are presented as No. (percentage) unless indicated otherwise.