Table 1.
Baseline demographics and clinical characteristics.
| BMI > 30 (N=173) | BMI <= 30 (N=119) | P-Value | |
|---|---|---|---|
|
| |||
| Demographics | |||
|
| |||
| Age | <0.01 | ||
| Median (25th, 75th) | 66.0 (54.0, 75.0) | 72.0 (62.0, 80.0) | |
| Mean (SD) | 64.3 ± 13.5 | 69.7 ± 13.1 | |
|
| |||
| White race | 126 (72.8%) | 94 (79.0%) | 0.23 |
|
| |||
| Male | 123 (71.1%) | 89 (74.8%) | 0.49 |
|
| |||
| Qualifying Furosemide Dose | 0.64 | ||
| Median (25th, 75th) | 120.0 (80.0, 160.0) | 120.0 (80.0, 160.0) | |
| Mean (SD) | 132.3 ± 52.4 | 128.9 ± 51.3 | |
|
| |||
| HF Hospitalization within 12 months prior to randomization | 130 (76.5%) | 81 (68.1%) | 0.11 |
|
| |||
| LVEF* | 0.03 | ||
| Median (25th, 75th) | 31.5 (20.0, 55.0) | 25.0 (20.0, 45.0) | |
| Mean (SD) | 36.6 ± 17.9 | 32.5 ± 16.7 | |
| ≥50% | 52 (31.0%) | 27 (22.9%) | 0.13 |
|
| |||
| Medical history | |||
|
| |||
| Ischemic Etiology | 95 (54.9%) | 77 (64.7%) | 0.09 |
|
| |||
| Diabetes Mellitus | 106 (61.3%) | 45 (37.8%) | <0.01 |
|
| |||
| Atrial Fibrillation/Flutter | 90 (52.0%) | 69 (58.0%) | 0.31 |
|
| |||
| Baseline medications | |||
|
| |||
| ACE or ARB | 111 (64.2%) | 72 (60.5%) | 0.53 |
|
| |||
| Aldosterone Antagonists | 46 (26.6%) | 38 (31.9%) | 0.32 |
|
| |||
| Beta blockers | 143 (82.7%) | 99 (83.2%) | 0.91 |
|
| |||
| Physical and laboratory findings | |||
|
| |||
| Systolic blood pressure | <0.01 | ||
| Median (25th, 75th) | 119.0 (106.0, 135.0) | 112.0 (101.0, 128.0) | |
| Mean (SD) | 121.3 ± 20.7 | 114.2 ± 16.6 | |
|
| |||
| Heart rate* | 0.65 | ||
| Median (25th, 75th) | 76.0 (67.0, 86.0) | 76.0 (70.0, 84.0) | |
| Mean (SD) | 78.3 ± 17.2 | 78.3 ± 13.5 | |
|
| |||
| Rales* | 100 (58.1%) | 69 (58.5%) | 0.95 |
|
| |||
| JVP >= 8cm* | 147 (91.3%) | 108 (93.1%) | 0.58 |
|
| |||
| SPO2 (%)* | 0.51 | ||
| Median (25th, 75th) | 96.0 (94.0, 98.0) | 96.0 (94.0, 99.0) | |
| Mean (SD) | 95.9 ± 3.0 | 96.1 ± 3.0 | |
|
| |||
| Serum creatinine (mg/dL) | 0.95 | ||
| Median (25th, 75th) | 1.40 (1.11, 1.82) | 1.44 (1.08, 1.85) | |
| Mean (SD) | 1.49 ± 0.50 | 1.50 ± 0.55 | |
|
| |||
| Serum cystatin C (mg/L) | 0.53 | ||
| Median (25th, 75th) | 1.51 (1.16, 1.92) | 1.45 (1.08, 1.89) | |
| Mean (SD) | 1.58 (0.56) | 1.54 ± 0.56 | |
|
| |||
| Sodium (mEq/L) | <0.01 | ||
| Median (25th, 75th) | 139.0 (137.0, 141.0) | 138.0 (135.0, 140.0) | |
| Mean (SD) | 138.7 ± 3.9 | 137.6 ± 3.4 | |
|
| |||
| NTproBNP (pg/mL)* | <0.01 | ||
| Median (25th, 75th) | 3404.0 (2005.0, 6929.0) | 7491.5 (4190.0, 14374.0) | |
| Mean (SD) | 5630.3 ± 6479.4 | 10135.0 ± 7898.0 | |
P-values for continuous variables are based on Wilcoxon rank-sum test. P-values for categorical variables are based upon Chi-square test.
*
Small number of responses missing; percentages are based on total known responses