Table 2.

Primary and secondary endpoints

	BMI > 30 (N=173)	BMI <= 30 (N=119)	P-Value

Global VAS AUC (72 Hours)			0.67
N	171	116
Median (25^th, 75^th)	4497 (3371, 5429)	4340 (3561, 5157)
Mean (SD)	4329 ± 1417	4180 ± 1452

Dyspnea VAS AUC (72 Hours)			0.67
N	171	116
Median (25^th, 75^th)	4803 (3483, 5759)	4719 (3900, 5461)
Mean (SD)	4588 ± 1558	4529 ± 1517

Free from congestion (%, 72 hours)	24/169 (14.2%)	16/114 (14.0%)	0.97

Fluid loss (ml, 72 hours)			0.02
N	141	95
Median (25^th, 75^th)	4114 (2501, 6262)	3193 (1404, 5306)
Mean (SD)	4631 ± 3184	3654 ± 3036

Change in NTproBNP (72 hours)			0.83
N	143	93
Median (25^th, 75^th)	−580 (−1856, 30)	−1669 (−4166, −103)
Mean (SD)	−1153 ± 3731	−2165 ± 4665

Creatinine change (72 hours)			0.01
N	170	115
Median (25^th, 75^th)	0.05 (−0.10, 0.22)	−0.02 (−0.14, 0.15)
Mean (SD)	0.09 ± 0.31	−0.00 ± 0.28

Creatinine change (60 days)			0.37
N	131	89
Median (25^th, 75^th)	0.05 (−0.15, 0.26)	0.03 (−0.14, 0.25)
Mean (SD)	0.11 ± 0.45	0.05 ± 0.41

Cystatin C change (72 hours)			0.04
N	143	94
Median (25^th, 75^th)	0.14 (0.01, 0.29)	0.06 (−0.07, 0.16)
Mean (SD)	0.17 ± 0.36	0.08 ± 0.28

Cystatin C change (60 days)			0.43
N	106	74
Median (25^th, 75^th)	0.11 (−0.08, 0.22)	0.05 (−0.10, 0.38)
Mean (SD)	0.21 ± 0.54	0.15 ± 0.36

Worsening renal function (%, 72 hours)	37/170 (21.8%)	15/115 (13.0%)	0.06

Worsening renal function (%, 60 days)	28/128 (21.9%)	19/85 (22.4%)	0.93

Time to discharge (days)			0.74
N	173	119
Median (25^th, 75^th)	6.0 (4.0, 9.0)	5.0 (3.0, 9.0)
Mean (SD)	7.9 ± 7.3	7.4 ± 7.8