Fig. 4.

(A) One month after the last exposure to the various stress conditions, a group of mice was re-exposed to the social interaction test (n=12). ES and PS exposure significantly reduced the time the mice spent interacting when compared to CON mice (p< 0.05, respectively). (B) A single day of fluoxetine injections was unable to reverse stress-induced social avoidance (p> 0.05, respectively). (C) Chronic (30 days) treatment with fluoxetine reversed the social interaction deficits previously observed in both ES- and PS-exposed mice (n=5–8). Data are presented as interaction times (in seconds) and as interaction ratios (Target/No Target) (mean ± SEM).