Table 1.
Fold Change in Astrocyte-Associated Genes 24 hr after transient focal ischemia by genotype
| Symbol | Description | WT | Hsp72Tg | References |
|---|---|---|---|---|
| Hmox1* | heme oxygenase (decycling) 1 | 5,98 | 8.45a | (Schipper et al., 2009) |
| Cxcl10* | chemokine (C-X-C motif) ligand 10 | 3,79 | 9.66 | (Wang et al., 1998) (17510981) |
| Lcn2* | lipocalin 2 | 33.88 | 38.68 | (Lee et al., 2009) |
| Cd14* | CD14 antigen | 13.38 | 16.61 | (Galea et al., 1996) |
| Socs3* | suppressor of cytokine signaling 3 | 12.78 | 22.63 | (Okada et al., 2006) |
| Il6* | interleukin 6 | 12.38 | 20.14 | (Lau and Yu, 2001; Van Wagoner et al., 1999) |
| Timp1* | tissue inhibitor of metalloproteinase 1 | 8.88 | 10.76 | (Rivera et al., 1997) |
| Spp1* | secreted phosphoprotein 1 | 8.34 | 6.39 a | (Ellison et al., 1998) |
| Serpina3n* | serine (or cysteine) peptidase inhibitor, clade A, member 3N | 7.59 | 6.89 a | (Rattner and Nathans, 2005) |
| Cxcl2* | chemokine (C-X-C motif) ligand 2 | 6.22 | 48.00 a | (Lu et al., 2005; Valles et al., 2006) |
| Serpine1* | serine (or cysteine) peptidase inhibitor, clade E, member 1 | 6.14 | 7.17 | (Vivien and Buisson, 2000; Yepes and Lawrence, 2004a; Yepes and Lawrence, 2004b) |
| Ccl2* | chemokine (C-C motif) ligand 2 | 5.61 | 17.04 | (Lawrence et al., 2006) (11384610) |
| Icam1* | intercellular adhesion molecule | 4.81 | 11.59 a | (Yin et al., 2004) (785406) |
| Tgfbi | transforming growth factor, beta induced | 4.55 | 7.52 | (Meeuwsen et al., 2003) |
| Cd44* | CD44 antigen | 4.39 | 5.27 a | (Girgrah et al., 1991; Haegel et al., 1993) |
| Vim* | Vimentin | 4.38 | 4.79 a | (Calvo et al., 1991; Ridet et al., 1997) |
| S100a11 | S100 calcium binding protein A11 (calgizzarin) | 4.11 | 4.50 a | (Deloulme et al., 2000) |
| Igfbp3 | insulin-like growth factor binding protein 3 | 3.98 | 4.44 | (Keene et al., 2009; Mewar and McMorris, 1997) |
| Gfap* | glial fibrillary acidic protein | 3.49 | 3.33 a | (Calvo et al., 1991; Ridet et al., 1997) |
| Osmr* | oncostatin M receptor | 3.47 | 4.17 | (Glezer and Rivest, 2010) |
| Thbd* | Thrombomodulin | 3.41 | 3.72 | (Pindon et al., 2000) |
| Akap12* | A kinase (PRKA) anchor protein (gravin) 12 | 3.21 | 5.03 | (Lee et al., 2003) |
| Cxcl1* | chemokine (C-X-C motif) ligand 1 | 3.05 | 11.43 | (Lu et al., 2005; Valles et al., 2006) (8152586) |
| Thbs1* | thrombospondin 1 | 2.52 | 3.08 a | (Lu and Kipnis, 2010) (12511771) |
| Cp* | Ceruloplasmin | 2.45 | 2.35 | (Hwang et al., 2004) (16542745) |
This group of genes was assembled from literature showing that these genes were upregulated by astrocytes upon stress or in a neurodegenerative disease. Changes in their expression levels in each genotype after focal ischemia relative to sham treatment of the same genotype is shown. Fold change values with a superscript “a” indicate a nonsignificant (p > 0.05) increase from sham to MCAO. Genes with an asterisk (*) were also identified as upregulated specifically in astrocytes following MCAO by Zamanian et al. (2012).