Table 2.

Results of Study 2. Each line gives the results for each SNP of a separate linear regression of g (score on the first principal component extracted from a battery of nine cognitive tests) on dosage of the minor allele (0, 1, or 2 copies), controlling for a cubic of age, a cubic of age interacted with sex, the first 10 principal components of the SNP genotype correlation matrix, and study cohort, with clustering by extended families, in the Framingham Heart Study dataset (N = 1759). The R² column gives the percentage of variance explained by a univariate regression of g on minor allele dosage for each SNP.

SNP	CHR	Gene	R2 (%)	Beta	Standard Error	t	p	MAF	Minor Allele	Major Allele
rs1018381	6p	DTNBP1	0.02	0.607	0.928	0.655	.51	.088	C	T
rs17571	11p	CTSD	0.06	−0.935	1.105	−0.846	.40	.086	A	G
rs1800497	11q	DRD2/ANKK1	0.14	−0.914	0.632	−1.448	.15	.202	A	G
rs2061174	7q	CHRM2	0.00	−0.009	0.600	−0.014	.10	.318	G	A
rs2760118	6p	SSADH (ALDH5A1)	0.23	−1.158	0.576	−2.011	.04	.309	T	C
rs4680	22q	COMT	0.02	−0.260	0.539	−0.481	.63	.486	G	A
rs6265	11p	BDNF	0.01	0.298	0.695	0.429	.67	.189	T	C
rs760761	6p	DTNBP1	0.01	0.218	0.687	0.317	.75	.191	A	G
rs8191992	7q	CHRNA4/CHRM2	0.00	−0.039	0.551	−0.071	.94	.440	T	A
rs821616	1q	DISC1	0.02	−0.387	0.608	−0.636	.53	.287	T	A

Note: CHR = Chromosome; MAF = Minor Allele Frequency.