Figure 5.

Ghrelin (delivered lateral ICV) activated PI3K (Fig. 5A) and Akt (Fig. 5B) signaling in the VHPC in chow-fed, but not Western diet-fed rats, whereas p44/42 MAPK signaling was not elevated by ghrelin (Fig. 5C). The food intake stimulatory effects of VHPC ghrelin were blunted with co-administration of the PI3K inhibitor LY294002 at 3hr and 6hr after injections (Fig. 5D). Data are mean ± SEM, * = p < 0.05 vs. vehicle.