Figure 1.

(A) Schematic drawing of the transverse section of the larynx in the rat, depicting the site of LPS or vehicle injection in the right vocal fold. (B) Photomicrograph of the right vocal fold depicts changes observed following 72 h after LPS injection; the magnified inset shows chronic inflammation and tissue re-organization at the site of LPS injection, characterized by the accumulation of macrophages and lymphocytes in the vocal fold mucosa, disintegrated muscle fibers, and increased vascularization and granulations. (C) Photomicrograph of the right vocal fold shows the site of vehicle injection; the magnified inset depicts the absence of formed inflammatory tissue response to trauma from the needle penetration as observed during LPS injection with only few scattered macrophages in the vocal fold tissue surrounding the needle tract. TA, thyroarytenoid muscle; AC, arytenoid cartilage; TC, thyroid cartilage; CC, cricoid cartilage.