Table 4.
Drugs associated with reactivation or enhanced replication of HHV-6 [a]
| Category | In vitro | In vivo [b] |
|---|---|---|
| HDAC inhibitor | Trichostatin A [*] | |
| Sodium n-butyrate | ||
| Antibiotics | Amoxicillin | |
| TMP–SMX | ||
| Minocycline | ||
| Vancomycin | ||
| Dapsone | ||
| Immunosuppressant | Hydrocortisone [*] | |
| Anti-inflammatory | Sulfasalazine | |
| Anesthetic | Trichloroethylene | |
| Anti-arrhythmic | Mexiletine | |
| Anticonvulsants | Carbamazepine [c] | Carbamazepine [c] |
| Valproic Acid [c] | ||
| Zonisamide | ||
| Phenobarbitol | ||
| Lamotrigine | ||
| Phenytoin | ||
| NSAIDs | Ibuprofen | |
| Naproxen | ||
| Other | Allopurinol | |
| TPA (12-O-tetradecanoylphorbol-13-acetate) [7] |
a
See Supplementary Table for additional information and references.
b
In vivo associations have been in the context of DIHS, DRESS, TEN, SJS, and AHS.
c
This drug has HDAC inhibitor properties.
*
Also shown to activate chromosomally integrated virus.
HHV-6, human herpesvirus 6; HDAC, histone deacetylase; DIHS, drug-induced hypersensitivity syndrome; DRESS, drug rash with eosinophilia and systemic symptoms; SJS, Stevens–Johnson syndrome; AHS; anticonvulsant-induced hypersensitiviy syndrome; TEN, toxic epidermal necrolysis; NSAIDs, non-steroidal anti-inflammatory drugs.