TABLE 2.
Genes Associated With Genetic Differences in KIM-R1 Response and Reported Functions
| Gene symbol | Gene name | Function |
|---|---|---|
| Pcsk5 | Proprotein convertase subtilisin/kexin type 5 | Critical role in cholesterol metabolism by controlling levels of circulating LDL |
| Csde1 | Cold shock domain containing E1, RNA binding | Unknown |
| Nr1h5 | Nuclear receptor subfamily 1, group H, member 5 | DNA binding, receptor activity, metal ion binding |
| Pde7a | Phosphodiesterase 7A | Cellular proliferation and cytokine production in NKT cells |
| Dnajc5b | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | Heat shock protein binding |
| Eif2ak2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Serine/threonine protein kinase that phosphorylates translation initiation factor EIF2S1, inhibiting protein synthesis |
| Eif4b | Eukaryotic translation initiation factor 4B | mRNA helicase |
| Mtfr1 | Mitochondrial fission regulator 1 | Mitochondrial protein that protects cells from oxidative stress |
| Pip5k1a | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | Phospholipid biosynthesis |
| Soat2 | Sterol O-acyltransferase 2 | Produces cholesterol esters from long-chain fatty acyl CoA and cholesterol; cholesterol absorption and secretion of very LDLs |
| Sptlc1 | Serine palmitoyltransferase, long chain base subunit 1 | Key enzyme in sphingolipid biosynthesis |
| Zfp740 | Zinc finger protein 740 | Transcription factor |