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Schematic structure of recombinant adeno-associated virus (AAV) vectors. AAV2/5RK.cpde6β and AAV2/8RK.cpde6β vectors encode the canine pde6β cDNA under the control of a human RK promoter (–112 bp to +87 bp region of the proximal promoter36). BGHpA, bovine growth hormone polyadenylation signal; cpde6β, canine pde6β cDNA; ITR, inverted terminal repeats from AAV2; RK, human rhodopsin kinase promoter.
