Figure 7.

Reduction of astrogliosis and improved myelination in icv-ic-iv-treated mice. (a) Anti-GFAP-stained brain sections from a (A) 35-day-old untreated affected, (B) 114-day-old wild type, and (C) 114-day-old treated mouse. (Original magnification: ×400). (b) Electron micrographs of the spinal cord from a (A) 35-day-old, untreated affected, (B) wild type, and (C) 140-day-old icv-ic-iv-treated mice. Demyelinated axons are shown by arrow heads and the tubular profiles, characteristic of globoid cell leukodystrophy (GLD), are shown by arrows (see B panel A). Scales are shown on the pictures.