Figure 7.

Muscle function recovery assessed by isometric tetanic contractions. (a) Example of weight-corrected maximal isometric tetanic contractions of the tibialis anterior compartment in a 4-month-old dystrophic dog (untreated and treated legs) compared to an age-matched control dog. Return to the baseline after stimulation shows a muscular memory, which is characteristic of the dystrophic muscle and is decreased in the treated compartment. (b) The box and whiskers plot shows the force, the error-type interval (height of the box, 95% confidence interval) and the standard deviation (top and bottom of the whiskers). Contraction forces of treated compartments (gray) are significantly increased compared to untreated counterparts (black) and moves toward normal (white). A Mann–Whitney U-test confirmed that force variation between left and right muscles were statistically significant (P < 0.05) for treated dogs.