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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jan 18;21(5):1350–1353. doi: 10.1016/j.bmcl.2011.01.044

Table 4.

Structures and activities of phthalimides 11.

graphic file with name nihms266642u4.jpg
Cmpd R1 R2 mGlu5 EC50 (nM)a % Glu Maxb Category
11a H H 5.9 104 Ago-PAM
11b graphic file with name nihms266642t5.jpg H 870 40 PAM
11c graphic file with name nihms266642t6.jpg H 900 76 PAM
11d graphic file with name nihms266642t4.jpg H 5,700 44 pAM
11e H m-F 35 99 Ago-PAM
11f H m-F, p-F 170 84 PAM
11g H p-F 160 88 PAM
11h H o-F 12 93 Ago-PAM
a

EC50s are the average of three determinations and are reproducible with a coefficient of variation of 0.3.

b

Determined at 30 μM test compound wherein %max vehicle is 10-30%.