Table 1.

Hits issued from screening the 1,4-naphthoquinone libraries.

compound	structure	% inhibition at 20 µM deprotonation	IC50 (µM) NADPH oxidation
		PBCV-1 ThyX
C8-C1 2-hydroxy-3-(4-methoxybenzyl)-1,4-naphthoquinone		78 ± 4	4.5
E11-C1 2-hydroxy-3-(2-oxo-2-phenylethyl)-1,4-naphthoquinone		36 ± 5	11.0
H3-C1 2-hydroxy-3-(2-oxo-2-(thiophen-2-yl)ethyl)-1,4-naphthoquinone		38 ± 3	7
F3-C1 2-hydroxy-3-(2-oxo-2-p-tolylethyl)-1,4-naphthoquinone		38 ± 7	7
G3-C1 2-hydroxy-3-(2-(4-methoxyphenyl)-2-oxoethyl)-1,4-naphthoquinone		22 ± 7	10
B3-C1 2-(5-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-ylamino)benzoic acid		12 ± 6	>10