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Demonstration of different mechanisms of action of licorice through inhibition of 11-ß-hydroxysteroid dehydrogenase type 2, 5 ß-reductase (which metabolizes aldosterone) and its direct action on the mineralocorticoid receptors causing sodium reabsorption and potassium secretion. MR, mineralocorticoid receptor; 11-ß-HSD 2, 11-ß-hydroxysteroid dehydrogenase type 2.
