FIG. 2.

Gray collie blood cell counts. Serial blood cell counts of a gray collie dog before and after treatment with recombinant canine G-CSF and G-CSF-lentivirus. Pretreatment values (open squares). Increasing doses of recombinant canine G-CSF administered subcutaneously were 0.5 μg/kg (open circles), 1.0 μg/kg (open diamonds), and 2.0 μg/kg (open triangles). Four sequential doses of G-CSF-lentivirus at 3×10⁷ infectious units per kilogram body weight were administered intramuscularly: first virus (solid black circles), second virus (solid red squares), third virus (solid blue diamonds), and fourth virus (solid green triangles). Shown are absolute neutrophil counts (A), monocytes (B), lymphocytes (C), hematocrit (D), and platelets (E). Red solid triangles in (A) are neutrophil values after subcutaneous administration of five sequential doses of recombinant canine G-CSF at 2.5 μg/kg. Color images available online at www.liebertpub.com/hum