Figure 7.

Model of the human anti-peptide (left) and mouse anti-peptide (right) repertoires. On the top, side view of the Connolly surface of the models. Bottom, models seen from the antigen perspective. Invariant V_Ls are colored in brown. V_Hs are colored in gray. Within the antigen-binding site, green represents fully randomized positions, i.e., 20 amino acids; blue positions diversified to Tyr, Asp, Ala, and Ser; red positions diversified to incorporate the most common anti-peptide SDRs. PDBID: 1MCP and 2IGF were used as template for modeling human V_L and V_H, respectively. Coordinates of the antibody 26-10 (PDBID 1IGI) were used for modeling the mouse anti-peptide repertoire. The models and Figures were created in Discovery Studio.