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. Author manuscript; available in PMC: 2013 Oct 11.
Published in final edited form as: J Med Chem. 2012 Sep 26;55(19):8375–8391. doi: 10.1021/jm3007596

Table 3.

Inhibition of P. falciparum D6 and C235 by selected compounds.

Compound D6 IC50 (nM) D6 R2 C235 IC50 (nM) C235 R2
Chloroquine 7 nM - 89 nM -
3i 3100 nM 0.93 >6000 nM 0.67
3j 1400 nM 0.96 1300 nM 0.97
7a 770 nM 0.97 690 nM 0.97
14a 2700 nM 0.95 2700 nM 0.87