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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Nature. 2012 Feb 29;483(7388):222–226. doi: 10.1038/nature10849

Figure 2. Reducing HDAC2 levels alleviates memory deficits.

Figure 2

a, Representative immunohistochemical images depicting HDAC2 in hippocampal area CA1 of CK-p25, shHDAC2, CK-p25, scr, and CON, scr animals; scale bar, 20μm. b, Quantitative assessment of (a), n=4-5 sections from 4 mice each. c, Quantitative PCR results of AcH4K12-immunoprecipitated chromatin in CK-p25, scr and CK-p25, shHDAC2 compared to CON, scr mice. d, Quantitative RT-PCR results of the same genes. (c, d, n=4-6 animals each). e, g, Representative immunohistochemical images depicting (c) Svp and (e) MAP2 immunoreactivity in the hippocampus stratum radiatum, scale bars c, 25μm, e, 20μm f, Quantitative assessment of (c), n=4 mice each. f, Freezing responses of CON, scr (n=18), CK-p25, scr (n=16) and CK-p25, shHDAC2 (n=16) mice 24 h after contextual fear conditioning. g, Escape latencies in a water maze task of CON, scr (n=19), CK-p25, scr (n=17) and CK-p25, shHDAC2 (n=19) animals. Data points are averages of two trials per day. h, Representative swim traces and time spent per quadrant during the water maze test (T, target quadrant, R=right, O=opposite, L=left of target). *p≤0.05; **p≤0.01; ***p≤0.001, values are mean ± s.e.m.