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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Nature. 2009 May 7;459(7243):55–60. doi: 10.1038/nature07925

Figure 2. HDAC2 knockout mice exhibit enhanced memory formation.

Figure 2

a. Immunohistochemical images showed the HDAC2 expression in the hippocampus of WT mice but not HDAC2KO mice. scale bar, 100μm b. Samples from hippocampal histone extraction showed the histone acetylation level changes in HDAC2KO mice. c. Freezing behaviour of HDAC2KO mice and control littermates (HDAC2 −/−, n = 9; WT, n = 11) during the contextual and tone-dependent memory test. d. Distance traveled during the initial 3 min exposure to the training box. e. Velocity during the training and the electric foot shock (I=0.8 mA). **, p<0.005.