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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Nature. 2009 May 7;459(7243):55–60. doi: 10.1038/nature07925

Figure 5. SAHA, an HDAC inhibitor, improves associative learning by targeting HDAC2.

Figure 5

a. Memory test for mice with contextual fear conditioning training (foot shock 1.0 mA). HDAC2OE mice (n=12, each group) and WT littermates (SAHA group, n=12; saline group, n=15) were treated with saline or SAHA (25mg/kg, i.p.) for 10 days before memory test. b. Immunostaining images of CA1 region from WT and HDAC2OE mice received chronic SAHA treatment or saline treatment. Py, pyramidal neuron layer; s.r., stratum radiatum, Scale bar=50μm, (n=12 for each group). c. Images of Golgi staining from CA1 region of hippocampus. For WT, naïve, n=23; SAHA, n=41; for HDAC2OE, naïve, n=21; SAHA, n=32. Scale bar: 10μm. d. Memory tests for mice with contextual fear conditioning training (foot shock 0.5 mA) after 10-day SAHA injection (25mg/kg, i.p.). WT mice (n=10, each group) and HDAC2 KO mice (n=8, each group). e. Immunostaining images of CA1 region from HDAC2KO mice received chronic SAHA treatment or saline treatment. Saline, n=15; SAHA, n=22. Scale bar=50μm. f. Images of Golgi staining of CA1 region from HDAC2KO mice. HDAC2KO, SAHA, n=24; naïve, n=27. *, p<0.05; **, p<0.005; ***, p<0.001