TABLE 2.

Associations among maternal serum PUFA, prenatal hair MeHg, and developmental outcomes of 5-y-old children¹

	PLS-TL			PLS-AC			PLS-VA			KBIT-VK
Variable	Coefficient	SE	P value	Coefficient	SE	P value	Coefficient	SE	P value	Coefficient	SE	P value
Model 1
Maternal serum DHA, mmol/L	41.3	19.3	0.03*	16.7	9.7	0.1	24.6	12.2	0.04*	3.3	10.5	0.8
Maternal serum AA, mmol/L	−15.8	6.5	0.02*	−7.5	3.2	0.02*	−8.3	4.1	0.04*	1.2	3.5	0.7
Prenatal hair MeHg, nmol/g	0.03	0.02	0.2	0.01	0.01	0.2	0.01	0.01	0.3	0.0	0.01	0.7
Model 2
Maternal serum DHA + EPA, mmol/L	31.7	16.6	0.1	13.1	8.3	0.1	18.6	10.5	0.1	0.01	8.9	1.0
Maternal serum AA, mmol/L	−14.7	6.4	0.02*	−7.1	3.2	0.03*	−7.6	4.0	0.1	1.9	3.5	0.6
Prenatal hair MeHg, nmol/g	0.03	0.02	0.2	0.01	0.01	0.2	0.01	0.01	0.3	0.01	0.01	0.6
Model 3
Maternal serum DHA, mmol/L	14.4	16.4	0.4	3.7	8.2	0.7	10.7	10.3	0.3	−1.1	8.7	0.9
Maternal serum (n-6) PUFA, mmol/L	−0.2	0.5	0.7	−0.1	0.3	0.8	−0.1	0.3	0.7	0.6	0.3	0.02*
Prenatal hair MeHg, nmol/g	0.03	0.02	0.1	0.02	0.01	0.1	0.02	0.01	0.2	0.0	0.01	0.7
Model 4
Maternal serum (n-3) PUFA, mmol/L	10.0	13.7	0.5	2.7	6.8	0.7	7.4	8.6	0.4	−1.5	7.2	0.8
Maternal serum (n-6) PUFA, mmol/L	−0.1	0.5	0.8	−0.1	0.2	0.8	−0.1	0.3	0.8	0.6	0.3	0.02*
Prenatal hair MeHg, nmol/g	0.03	0.02	0.1	0.02	0.01	0.1	0.02	0.01	0.2	0.0	0.01	0.7
Model 5
Maternal serum AA:DHA ratio	−0.6	0.4	0.1	−0.3	0.2	0.1	−0.4	0.2	0.1	−0.0	0.2	0.9
Prenatal hair MeHg, nmol/g	0.03	0.02	0.1	0.01	0.01	0.2	0.02	0.01	0.2	0.01	0.01	0.6

¹Significant results defined by *P < 0.05, from fully adjusted multiple linear regression models. AA, arachidonic acid; KBIT-VK, Kaufman Brief Intelligence Test-verbal knowledge; MeHg, methylmercury; PLS-AC, Preschool Language Scale-auditory comprehension; PLS-TL, Preschool Language Scale-total language score; PLS-VA, Preschool Language Scale-verbal ability.