. 2012 Sep 18;142(11):2040–2049. doi: 10.3945/jn.112.162198

TABLE 4.

Regional DA, DOPAC, 5HT, and 5HIAA concentrations of CN-40, FID-40, FID-400, and TID rats at P21¹

	Brain region	CN-40	FID-40	FID-400	TID
		nmol/g tissue
DA	Cerebellum	2.02 ± 0.53^a,b	2.47 ± 0.95^a	0.14 ± 0.07^b	0.17 ± 0.05^ab
	Frontal cortex	0.26 ± 0.34^a,b	2.41 ± 1.66^a	0.17 ± 0.10^b	0.15 ± 0.07^b
	Striatum	13.1 ± 5.36^b	20.4 ± 7.10^a	18.8 ± 5.04^a	7.6 ± 4.55^c
	Hippocampus	1.74 ± 1.79^a,b	3.02 ± 1.47^a	0.10 ± 0.06^b	0.12 ± 0.08^b
	Midbrain	2.13 ± 1.72^a,b	3.73 ± 3.25^a	1.34 ± 1.43^b	0.86 ± 0.94^b
DOPAC	Cerebellum	5.17 ± 1.78^a,b	5.89 ± 2.18^a	4.50 ± 1.88^a,b	3.75 ± 1.40^b
	Frontal cortex	4.85 ± 2.57^b	8.89 ± 3.50^a	5.62 ± 2.30^b	4.90 ± 1.36^b
	Striatum	14.8 ± 3.08^b	19.8 ± 5.55^a	11.0 ± 2.99^c	9.68 ± 2.88^c
	Hippocampus	5.87 ± 2.59^b	8.79 ± 4.16^a	5.18 ± 2.82^b	5.48 ± 2.23^b
	Midbrain	6.22 ± 3.34^a,b	7.29 ± 4.12^a	6.90 ± 2.47^a,b	4.69 ± 2.78^b
5HT	Cerebellum	0.49 ± 0.26^a,b	1.31 ± 0.48^a	0.37 ± 0.49^b	0.17 ± 0.09^b
	Frontal cortex	1.38 ± 1.47^b	2.51 ± 1.73^a	0.45 ± 0.23^b,c	0.39 ± 0.15^c
	Striatum	1.67 ± 0.65^a	2.94 ± 0.97^a	0.69 ± 0.31^b	0.46 ± 0.23^b
	Hippocampus	1.64 ± 1.44^b	3.03 ± 1.97^a	0.86 ± 1.03^c	0.57 ± 0.33^c
	Midbrain	2.15 ± 1.27^b	3.22 ± 3.03^a	2.19 ± 2.35^b	1.79 ± 1.76^b
5HIAA	Cerebellum	3.01 ± 1.61^a	1.72 ± 0.61^a	1.52 ± 0.68^a	1.66 ± 0.60^a
	Frontal cortex	2.75 ± 0.97^a	2.27 ± 0.94^a	1.61 ± 0.61^a	1.56 ± 0.54^a
	Striatum	4.92 ± 2.21^a	4.62 ± 1.40^a	2.77 ± 1.30^a	3.11 ± 2.47^a
	Hippocampus	11.2 ± 12.7^a	5.17 ± 7.72^b,c	6.00 ± 1.52^b	2.43 ± 1.00^c
	Midbrain	5.43 ± 2.29^a	4.77 ± 1.54^a	4.30 ± 2.62^a	2.46 ± 1.09^a

Values are means ± SD, n = 11–13 litters/diet group. Means in a row without a common letter differ, P < 0.05. CN-40, control; DA, dopamine; DOPAC, 3,4 dihydroxyphenylacetic acid; FID-40, formerly iron deficient fed 0.04-g/kg iron diet beginning at postnatal d 8; FID-400, formerly iron deficient fed 0.4-g/kg iron diet beginning at postnatal d 8; 5HIAA, 5-hydroxyindoleacetic acid; 5HT, serotonin; P, postnatal day; TID, totally iron deficient.