TABLE 4.
Brain region | CN-40 | FID-40 | FID-400 | TID | |
nmol/g tissue | |||||
DA | Cerebellum | 2.02 ± 0.53a,b | 2.47 ± 0.95a | 0.14 ± 0.07b | 0.17 ± 0.05ab |
Frontal cortex | 0.26 ± 0.34a,b | 2.41 ± 1.66a | 0.17 ± 0.10b | 0.15 ± 0.07b | |
Striatum | 13.1 ± 5.36b | 20.4 ± 7.10a | 18.8 ± 5.04a | 7.6 ± 4.55c | |
Hippocampus | 1.74 ± 1.79a,b | 3.02 ± 1.47a | 0.10 ± 0.06b | 0.12 ± 0.08b | |
Midbrain | 2.13 ± 1.72a,b | 3.73 ± 3.25a | 1.34 ± 1.43b | 0.86 ± 0.94b | |
DOPAC | Cerebellum | 5.17 ± 1.78a,b | 5.89 ± 2.18a | 4.50 ± 1.88a,b | 3.75 ± 1.40b |
Frontal cortex | 4.85 ± 2.57b | 8.89 ± 3.50a | 5.62 ± 2.30b | 4.90 ± 1.36b | |
Striatum | 14.8 ± 3.08b | 19.8 ± 5.55a | 11.0 ± 2.99c | 9.68 ± 2.88c | |
Hippocampus | 5.87 ± 2.59b | 8.79 ± 4.16a | 5.18 ± 2.82b | 5.48 ± 2.23b | |
Midbrain | 6.22 ± 3.34a,b | 7.29 ± 4.12a | 6.90 ± 2.47a,b | 4.69 ± 2.78b | |
5HT | Cerebellum | 0.49 ± 0.26a,b | 1.31 ± 0.48a | 0.37 ± 0.49b | 0.17 ± 0.09b |
Frontal cortex | 1.38 ± 1.47b | 2.51 ± 1.73a | 0.45 ± 0.23b,c | 0.39 ± 0.15c | |
Striatum | 1.67 ± 0.65a | 2.94 ± 0.97a | 0.69 ± 0.31b | 0.46 ± 0.23b | |
Hippocampus | 1.64 ± 1.44b | 3.03 ± 1.97a | 0.86 ± 1.03c | 0.57 ± 0.33c | |
Midbrain | 2.15 ± 1.27b | 3.22 ± 3.03a | 2.19 ± 2.35b | 1.79 ± 1.76b | |
5HIAA | Cerebellum | 3.01 ± 1.61a | 1.72 ± 0.61a | 1.52 ± 0.68a | 1.66 ± 0.60a |
Frontal cortex | 2.75 ± 0.97a | 2.27 ± 0.94a | 1.61 ± 0.61a | 1.56 ± 0.54a | |
Striatum | 4.92 ± 2.21a | 4.62 ± 1.40a | 2.77 ± 1.30a | 3.11 ± 2.47a | |
Hippocampus | 11.2 ± 12.7a | 5.17 ± 7.72b,c | 6.00 ± 1.52b | 2.43 ± 1.00c | |
Midbrain | 5.43 ± 2.29a | 4.77 ± 1.54a | 4.30 ± 2.62a | 2.46 ± 1.09a |
Values are means ± SD, n = 11–13 litters/diet group. Means in a row without a common letter differ, P < 0.05. CN-40, control; DA, dopamine; DOPAC, 3,4 dihydroxyphenylacetic acid; FID-40, formerly iron deficient fed 0.04-g/kg iron diet beginning at postnatal d 8; FID-400, formerly iron deficient fed 0.4-g/kg iron diet beginning at postnatal d 8; 5HIAA, 5-hydroxyindoleacetic acid; 5HT, serotonin; P, postnatal day; TID, totally iron deficient.