. 2012 Sep 18;142(11):2040–2049. doi: 10.3945/jn.112.162198

TABLE 5.

Regional DA, DOPAC, 5HT, and 5HIAA concentrations of CN-40, FID-40, FID-400, and TID rats at P100¹

	Brain region	CN-40	FID-40	FID-400	TID
		nmol/g tissue
DA	Cerebellum	1.78 ± 0.55^a	2.09 ± 0.77^a	0.19 ± 0.15^a	0.21 ± 0.23^a
	Frontal cortex	1.06 ± 0.94^a	2.63 ± 1.04^a	0.16 ± 0.09^a	0.42 ± 0.26^a
	Striatum	45.3 ± 11.7^b	61.9 ± 14.9^a	43.8 ± 15.2^b	44.9 ± 17.9^b
	Hippocampus	0.94 ± 1.04^a	2.55 ± 1.09^a	0.15 ± 0.19^a	0.24 ± 0.08^a
	Midbrain	1.66 ± 1.29^a	3.56 ± 2.02^a	0.49 ± 0.34^a	0.86 ± 0.83^a
DOPAC	Cerebellum	7.13 ± 1.96^b	11.5 ± 2.73^a	5.50 ± 2.27^b	5.08 ± 1.59^b
	Frontal cortex	7.40 ± 1.82^b	10.6 ± 2.70^a	5.81 ± 1.70^b,c	5.15 ± 2.00^c
	Striatum	15.5 ± 3.72^b,c	21.1 ± 4.98^a	13.8 ± 6.20^c	16.5 ± 5.28^b
	Hippocampus	6.79 ± 3.14^b	10.5 ± 2.93^a	5.07 ± 1.71^b,c	3.85 ± 1.84^c
	Midbrain	6.85 ± 3.51^b	11.2 ± 2.30^a	5.41 ± 2.22^b	5.25 ± 1.18^b
5HT	Cerebellum	1.85 ± 3.01^a	1.22 ± 0.38^a,b	0.16 ± 0.16^b	0.21 ± 0.15^a,b
	Frontal cortex	3.06 ± 1.50^b	6.26 ± 3.19^a	1.57 ± 0.66^c	1.50 ± 0.71^c
	Striatum	4.21 ± 2.48^b	7.19 ± 2.53^a	1.87 ± 1.58^c	1.43 ± 0.85^c
	Hippocampus	2.45 ± 1.60^b	4.78 ± 2.38^a	0.76 ± 0.29^c	1.14 ± 0.50^b,c
	Midbrain	5.85 ± 2.99^b	9.37 ± 3.26^a	2.12 ± 2.84^c	2.46 ± 1.41^c
5HIAA	Cerebellum	1.11 ± 0.20^a	0.90 ± 0.77^a	0.38 ± 0.18^a	0.63 ± 0.39^a
	Frontal cortex	2.55 ± 1.05^a	2.97 ± 0.78^a	1.27 ± 0.50^a	1.44 ± 0.59^a
	Striatum	6.36 ± 2.72^a,b	8.10 ± 2.64^a	2.70 ± 1.33^c	3.26 ± 2.37^b,c
	Hippocampus	11.1 ± 16.0^a	3.92 ± 5.39^b	0.95 ± 0.37^b	.28 ± 0.84^b
	Midbrain	11.3 ± 13.6^a	6.35 ± 9.08^b	1.86 ± 1.15^c	1.52 ± 1.16^c

Values are means ± SD, n = 11–13 litters/diet group. Means in a row without a common letter differ, P < 0.05. CN-40, control; DA, dopamine; DOPAC, 3,4 dihydroxyphenylacetic acid; FID-40, formerly iron deficient fed 0.04-g/kg iron diet beginning at postnatal d 8; FID-400, formerly iron deficient fed 0.4-g/kg iron diet beginning at postnatal d 8; 5HIAA, 5-hydroxyindoleacetic acid; 5HT, serotonin; P, postnatal day; TID, totally iron deficient.