TABLE 5.
Brain region | CN-40 | FID-40 | FID-400 | TID | |
nmol/g tissue | |||||
DA | Cerebellum | 1.78 ± 0.55a | 2.09 ± 0.77a | 0.19 ± 0.15a | 0.21 ± 0.23a |
Frontal cortex | 1.06 ± 0.94a | 2.63 ± 1.04a | 0.16 ± 0.09a | 0.42 ± 0.26a | |
Striatum | 45.3 ± 11.7b | 61.9 ± 14.9a | 43.8 ± 15.2b | 44.9 ± 17.9b | |
Hippocampus | 0.94 ± 1.04a | 2.55 ± 1.09a | 0.15 ± 0.19a | 0.24 ± 0.08a | |
Midbrain | 1.66 ± 1.29a | 3.56 ± 2.02a | 0.49 ± 0.34a | 0.86 ± 0.83a | |
DOPAC | Cerebellum | 7.13 ± 1.96b | 11.5 ± 2.73a | 5.50 ± 2.27b | 5.08 ± 1.59b |
Frontal cortex | 7.40 ± 1.82b | 10.6 ± 2.70a | 5.81 ± 1.70b,c | 5.15 ± 2.00c | |
Striatum | 15.5 ± 3.72b,c | 21.1 ± 4.98a | 13.8 ± 6.20c | 16.5 ± 5.28b | |
Hippocampus | 6.79 ± 3.14b | 10.5 ± 2.93a | 5.07 ± 1.71b,c | 3.85 ± 1.84c | |
Midbrain | 6.85 ± 3.51b | 11.2 ± 2.30a | 5.41 ± 2.22b | 5.25 ± 1.18b | |
5HT | Cerebellum | 1.85 ± 3.01a | 1.22 ± 0.38a,b | 0.16 ± 0.16b | 0.21 ± 0.15a,b |
Frontal cortex | 3.06 ± 1.50b | 6.26 ± 3.19a | 1.57 ± 0.66c | 1.50 ± 0.71c | |
Striatum | 4.21 ± 2.48b | 7.19 ± 2.53a | 1.87 ± 1.58c | 1.43 ± 0.85c | |
Hippocampus | 2.45 ± 1.60b | 4.78 ± 2.38a | 0.76 ± 0.29c | 1.14 ± 0.50b,c | |
Midbrain | 5.85 ± 2.99b | 9.37 ± 3.26a | 2.12 ± 2.84c | 2.46 ± 1.41c | |
5HIAA | Cerebellum | 1.11 ± 0.20a | 0.90 ± 0.77a | 0.38 ± 0.18a | 0.63 ± 0.39a |
Frontal cortex | 2.55 ± 1.05a | 2.97 ± 0.78a | 1.27 ± 0.50a | 1.44 ± 0.59a | |
Striatum | 6.36 ± 2.72a,b | 8.10 ± 2.64a | 2.70 ± 1.33c | 3.26 ± 2.37b,c | |
Hippocampus | 11.1 ± 16.0a | 3.92 ± 5.39b | 0.95 ± 0.37b | .28 ± 0.84b | |
Midbrain | 11.3 ± 13.6a | 6.35 ± 9.08b | 1.86 ± 1.15c | 1.52 ± 1.16c |
Values are means ± SD, n = 11–13 litters/diet group. Means in a row without a common letter differ, P < 0.05. CN-40, control; DA, dopamine; DOPAC, 3,4 dihydroxyphenylacetic acid; FID-40, formerly iron deficient fed 0.04-g/kg iron diet beginning at postnatal d 8; FID-400, formerly iron deficient fed 0.4-g/kg iron diet beginning at postnatal d 8; 5HIAA, 5-hydroxyindoleacetic acid; 5HT, serotonin; P, postnatal day; TID, totally iron deficient.