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. 2012 Nov 6;14(12):1452–1464. doi: 10.1093/neuonc/nos270

Fig. 2.

Fig. 2.

Concomitant treatment with TMZ and DEAB reduced the clonogenic capacity of GBM cell lines. (A) Colony formation assay demonstrates that the clonogenic capacity of LN18 exposed to 200 µM TMZ in combination with 100 µM DEAB for 10 days was significantly attenuated. (B) TMZ in combination with ALDH1A1 inhibition impaired sphere formation. Neurospheres of LN18, T98G, and R28 cells decreased in size and number after TMZ and DEAB administration; **P < .01, ***P < .001; mean values are shown above the box plots. Scale bar = 100 µM.