Table III.
Repetitive element DNA methylation and breast cancer risk, overall and stratified by source of DNA, the New York site of the BCFR
| Conditional Logistic (Discordant Case/Control) OR (95% CI) | |||
|---|---|---|---|
| ORc (95%CI) | ORd (95%CI) | ORd (95%CI) | |
| Sat2 | Pooled (N = 593) | Granulocyte (N = 206) | Total WBC (N = 387) |
| Q1 (<=25.8) | 1.62 (0.86–3.05) | 0.92 (0.34–2.47) | 2.12 (0.88–5.11) |
| Q2 (>25.8–37.7) | 1.44 (0.80–2.61) | 1.73 (0.67–4.44) | 1.44 (0.64–3.23) |
| Q3 (>37.7–52.5) | 1.34 (0.79–2.25) | 1.44 (0.65–3.23) | 1.37 (0.67–2.80) |
| Q4 (>52.5) | 1.00 | 1.00 | 1.00 |
| P trend | 0.15 | 0.84 | 0.11 |
| OR per 1 unit decrease in log(Sat2) | 1.44 (0.94–2.20) | 1.04 (0.59–1.85) | 2.09 (1.09–4.03) |
| LINE-1 | Pooled (N = 590) | Granulocyte (N = 205) | Total WBC (N = 385) |
| Q1 (<=72.9) | 0.94 (0.51–1.72) | 1.19 (0.48– 2.96) | 0.97 (0.41–2.32) |
| Q2 (>72.9–99.3) | 1.02 (0.58–1.79) | 0.69 (0.25–1.91) | 1.17 (0.54–2.55) |
| Q3 (>99.3–125.7) | 0.90 (0.53–1.51) | 0.64 (0.28–1.46) | 1.11 (0.54–2.28) |
| Q4 (>125.7) | 1.00 | 1.00 | 1.00 |
| P trend | 0.95 | 0.92 | 0.92 |
| OR per 1 unit decrease in log (LINE-1) | 0.99 (0.63–1.56) | 0.94 (0.50–1.77) | 1.11 (0.57–2.14) |
| Alu | Pooled (N = 593) | Granulocyte (N = 206) | Total WBC (N = 387) |
| Q1 (<=73.0) | 1.16 (0.63–2.13) | 0.90 (0.35–2.30) | 1.42 (0.62–3.27) |
| Q2 (>73.0–92.9) | 0.76 (0.40–1.42) | 0.33 (0.09–1.19) | 1.06 (0.49–2.26) |
| Q3 (>92.9–117.8) | 1.21 (0.72–2.02) | 1.07 (0.33–3.45) | 1.35 (0.75–2.43) |
| Q4 (>117.8) | 1.00 | 1.00 | 1.00 |
| P trend | 0.73 | 0.86 | 0.46 |
| OR per 1 unit decrease in log(Alu) | 1.18 (0.72–1.93) | 1.13 (0.61–2.09) | 1.48 (0.61–3.61) |
| LINE-1 Pyrosequencing | Pooled (N = 613) | Granulocyte (N = 217) | Total WBC (N = 396) |
| Q1 (<=73.4) | 0.81 (0.46–1.45) | 0.45 (0.14–1.38) | 0.93 (0.46–1.89) |
| Q2 (>73.4–75.0) | 0.58 (0.34–0.97) | 0.88 (0.39–1.97) | 0.44 (0.22–0.88) |
| Q3 (>75.0–76.1) | 0.60 (0.37–1.00) | 0.73 (0.34–1.56) | 0.52 (0.26–1.04) |
| Q4 (>76.1) | 1.00 | 1.00 | 1.00 |
| P trend | 0.33 | 0.30 | 0.73 |
| OR per 1 unit decrease | 0.97 (0.90–1.05) | 0.89 (0.75–1.05) | 1.01 (0.92-1.11) |
aAdjusted for age at blood draw, smoking status.
bStratified by source, adjusted for age at blood draw, smoking status.
cAdjusted for age at blood draw.
dStratified by source, adjusted for age at blood draw.