Table II.

Meat mutagen–SNP interaction and risk of colorectal adenoma and cancer for all interactions with a P ≤ 0.10

	Gene/gene region	dbSNP identifier	Main effect P valuea		Pinteractionb
Adenoma
	B[a]P
	GSTM3c	rs15864		0.75	0.07
	UGT1A locus	rs1105880		0.96	0.04
	UGT1A locus	rs12623271		0.44	0.04
	UGT1A locus	rs10168416		0.83	0.07
	PhIP
	UGT1A locus	rs871514		0.06	0.09
	UGT1A locus	rs28969701		0.40	0.08
	UGT1A locus	rs2018985		0.06	0.05
	UGT1A locus	rs10197460		0.37	0.09
	AHR	rs4236290		0.63	0.05
	EPHX1d	rs2671272		0.34	0.08
	MeIQx
	UGT1A locus	rs7571337		0.62	0.07
	NAT1	rs6586714		0.64	0.001*
	DiMeiQx
	CYP2C9	rs9332197		0.47	0.09
	EPHX1d	rs2671272		0.34	0.05
	EPHX1e	rs868966		0.27	0.03
	Combined nitrate and nitrite
	—	—		—	—
Cancer
	B[a]P
	AHR	rs2066853		0.21	0.07
	UGT1A locus	rs6714486		0.50	0.06
	UGT1A locus	rs17868299		0.67	0.05
	PhIP
	—	—		—	—
	MeIQx
	UGT1A locus	rs2011404		0.30	0.08
	CYP2E1	rs915908		0.63	0.05
	DiMeiQx
	UGT1A locus	rs6717546		0.52	0.04
	Combined nitrate and nitrite
	UGT1A locus	rs12466997		0.17	0.08

^aP value is for main effect of SNP on colorectal adenoma and cancer risk (P-values not corrected for multiple testing). Adjusted for age, sex and ethnicity and assuming a log-additive model.

^bP value is for a test for interaction using the likelihood ratio test comparing models with and without the cross-product of SNP for the given gene and the median of the categories of meat mutagen intake. P-values not corrected for multiple testing. Adjusted for age, sex and ethnicity and assuming a dominant model.

^cSNP located within 10kb downstream of EPS8L3.

^dSNP located within 10kb downstream of TMEM63A.

^eSNP located within 10kb upstream of LEFTY3.

^*statistically significant at P<0.05 after adjustment for multiple testing