Table III.
Association between meat mutagen intake and colorectal adenoma and cancer risk stratified by genotypes for which mutagen–SNP interactions were P < 0.05
| Mutagen exposure | ||||||||||||||||||
| Mutagene | Gene | SNP | Geno-type | Low | Medium | High | P trend | P interacta | ||||||||||
| Ca/Co | REF | Ca/Co | ORa | (95% CI) | Ca/Co | ORa | (95% CI) | |||||||||||
| Adenoma | B[a]P | UGT1A | rs12623271 | CC | 151/184 | REF | 173/181 | 1.17 | (0.87, 1.58) | 89/123 | 0.91 | (0.75, 1.15) | 0.35 | 0.04 | ||||
| CG+GG | 315/357 | REF | 313/388 | 0.93 | (0.75, 1.15) | 163/153 | 1.25 | (0.95, 1.64) | 0.06 | |||||||||
| PhIP | UGT1A | rs2018985 | AA | 164/202 | REF | 177/199 | 1.15 | (0.85, 1.55) | 75/120 | 0.82 | (0.57, 1.19) | 0.21 | 0.05 | |||||
| AG+GG | 309/345 | REF | 314/359 | 0.97 | (0.77, 1.21) | 164/159 | 1.15 | (0.88, 0.52) | 0.26 | |||||||||
| PhIP | AHR | rs4236290 | TT | 366/411 | REF | 380/442 | 0.98 | (0.80, 1.20) | 183/229 | 0.92 | (0.72, 1.17) | 0.49 | 0.05 | |||||
| TC+CC | 105/136 | REF | 111/115 | 1.24 | (0.85, 1.80) | 57/50 | 1.45 | (0.91, 2.31) | 0.14 | |||||||||
| MeIQx | NAT1 | rs6586714 | GG | 330/413 | REF | 357/390 | 1.20 | (0.97, 1.47) | 196/182 | 1.43 | (1.11, 1.85) | 0.007 | 0.001 | |||||
| GA+AA | 90/87 | REF | 102/130 | 0.74 | (0.49, 1.10) | 38/69 | 0.50 | (0.30, 0.84) | 0.01 | |||||||||
| DiMeIQx | EPHX1 | rs2671272b | GG | 292/329 | REF | 288/352 | 0.93 | (0.74, 1.16) | 146/186 | 0.91 | (0.69, 1.20) | 0.51 | 0.05 | |||||
| GA+AA | 198/221 | REF | 173/103 | 0.93 | (0.71, 1.24) | 107/91 | 1.30 | (0.92, 1.84) | 0.12 | |||||||||
| DiMeIQx | EPHX1 | rs868966c | AA | 122/167 | REF | 142/170 | 1.12 | (0.80, 1.55) | 85/78 | 1.45 | (0.98, 2.15) | 0.06 | 0.03 | |||||
| AG+GG | 368/383 | REF | 319/388 | 0.87 | (0.70, 1.07) | 169/200 | 0.91 | (0.70, 1.17) | 0.51 | |||||||||
| Cancer | B[a]P | UGT1A | rs17868299 | CC | 136/147 | REF | 135/125 | 1.18 | (0.84, 1.66) | 54/67 | 0.92 | (0.59, 1.42) | 0.52 | 0.05 | ||||
| CT | 6/19 | REF | 17/12 | 4.67 | (1.31, 16.7) | 12/8 | 6.04 | (1.39, 24.2) | 0.06 | |||||||||
| MeIQx | CYP2E1 | rs915908 | GG | 107/107 | REF | 122/117 | 1.05 | (0.73, 1.53) | 42/63 | 0.68 | (0.40, 1.08) | 0.08 | 0.05 | |||||
| GA+AA | 41/50 | REF | 33/37 | 1.07 | (0.56, 2.05) | 18/13 | 1.69 | (0.71, 4.00) | 0.23 | |||||||||
| DiMeIQx | UGT1A | rs6717546 | GG | 68/75 | REF | 60/66 | 1.04 | (0.64, 1.70) | 35/25 | 1.53 | (0.82, 2.86) | 0.16 | 0.04 | |||||
| GA+AA | 90/89 | REF | 72/85 | 0.83 | (0.53, 1.27) | 34/50 | 0.68 | (0.39, 1.16) | 0.18 | |||||||||
Meat mutagens classified as low (0–39th percentile), medium (40th–79th percentile) and high (≥80th percentile) intake.
aP-value is for a test for interaction using the likelihood ratio test comparing models with and without the cross-product of SNP for the given gene and the median of the categories of meat mutagen intake. P-values not corrected for multiple testing. Adjusted for age, sex and ethnicity and assuming a dominant model.
b SNP located within 10kb downstream of TMEM63A.
c SNP located within 10kb upstream of LEFTY3.