Table II.

Highly mutated genes and their associated pathways in lung cancer

Set	Regulatory process or pathway	Representative altered genes	Adjusted P values
Common	DNA damage control	TP53, MYO5A,POT1, DAXX, RB1, NBN	2E-14
	c-jun N-terminal kinase signaling	TP53, DAXX, PLCB1, PIK3CG, ATF2	3E-21
	Role of SUMO in p53 regulation	TP53, DAXX	5E-20
	Hepatocyte growth factor signaling in pancreatic cancer	TP53, HGF	2E-18
	Transforming growth factor-beta signaling	TP53, ATF2	5E-12
ADC	Mitogen-activated protein kinase signaling	KRAS and NOX4	3E-04
SCC	Invasion	DDI1, PROC, MMP16, HSPA6, PCCB, LCT and AOX1	2E-03
	Small GTPase signaling	WNK1, PLCXD3, PREX2, FMN2, DAB1 and CD36	5E-03
	ECM remodeling	LAMB1 and MMP16	7E-04