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. 2012 May 12;33(7):1340–1345. doi: 10.1093/carcin/bgs160

Table II.

Association of DNA methylation with HCC overall risk by age at HCC diagnosis

DNA methylation	Total			Age at diagnosis with HCC
	Cases/controls			≤62 years	>62 years
	305/1254			126/447	167/582
	OR (95% CI)	AdjOR^a (95% CI)		AdjOR^a (95% CI)	AdjOR^a (95% CI)
LINE-1
1U decrease	1.01 (0.93–1.08)	1.02 (0.94–1.10)		1.01 (0.86–1.15)	0.98 (0.87–1.09)
Quartile
Q4 (>77.8)	1.0	1.0		1.0	1.0
Q3 (76.4–77.8)	1.12 (0.77–1.63)	1.11 (0.74–1.66)		1.47 (0.73–2.97)	0.97 (0.57–1.62)
Q2 (74.6–76.4)	1.28 (0.84–1.95)	1.26 (0.81–1.97)		1.03 (0.47–2.25)	1.37 (0.76–2.47)
Q1a (<74.6)	0.88 (0.54–1.43)	0.92 (0.55–1.54)		0.89 (0.39–2.04)	0.80 (0.37–1.74)
	P _trend = 0.82	P _trend = 0.96		P _trend = 0.60	P _trend = 0.93
logSat2
1U decrease	1.47 (0.90–2.40)	1.77(1.06–2.95)		2.47 (1.06–5.73)	1.67 (0.84–3.32)
Quartile
Q4 (>4.9)	1.0	1.0		1.0	1.0
Q3 (4.6–4.9)	0.86 (0.59–1.26)	0.99 (0.66–1.50)		1.05 (0.53–2.09)	1.18 (0.68–2.07)
Q2 (4.3–4.6)	0.96 (0.66–1.41)	1.18 (0.78–1.78)		1.36 (0.67–2.76)	1.15 (0.65–2.04)
Q1b (<4.3)	1.35 (0.94–1.95)	1.49 (1.00–2.22)		2.37 (1.15–4.88)	1.46 (0.84–2.52)
	P _trend = 0.07	P _trend = 0.03		P _trend = 0.01	P _trend = 0.20

^aAdjOR, ORs adjusted for age, smoking, alcohol consumption and HBsAg status.

^bHypomethylation.

Bold value indicts the association is statistically significant at the p value of 0.05