Table III.
Association of DNA methylation with HCC by hepatitis B virus infection status
| DNA methylation | HBV+ | HBV− | ||
| Cases/controls | Cases/controls | |||
| (188/199) | AdjORa(95% CI) | (113/342) | AdjORa(95% CI) | |
| LINE-1 | ||||
| 1U decrease | 185/198 | 1.11 (0.98–1.26) | 113/341 | 0.95 (0.81–1.12) |
| Quartile | ||||
| Q4 (>77.8) | 38/47 | 1.0 | 33/91 | 1.0 |
| Q3 (76.4–77.8) | 50/48 | 2.39 (1.06–5.39) | 32/113 | 0.77 (0.40–1.49) |
| Q2 (74.6–76.4) | 50/55 | 2.09 (0.91–4.77) | 37/83 | 1.01 (0.50–2.07) |
| Q1b (74.6) | 47/48 | 2.28 (0.95–5.51) | 11/54 | 0.51 (0.19–1.36) |
| P trend = 0.14 | P trend = 0.45 | |||
| log Sat2 | ||||
| 1U decrease | 186/196 | 2.19 (1.00–4.89) | 111/338 | 1.81 (0.68-4.82) |
| Quartile | ||||
| Q4 (>4.9) | 47/60 | 1.0 | 25/92 | 1.0 |
| Q3 (4.6–4.9) | 35/47 | 1.23 (0.61–2.46) | 27/75 | 1.29 (0.66–2.54) |
| Q2 (4.3–4.6) | 43/42 | 1.82 (0.90–3.66) | 26/92 | 1.15 (0.58–2.28) |
| Q1b (<4.3) | 61/47 | 1.91 (0.92–3.96) | 33/79 | 1.75 (0.89–3.42) |
| P trend = 0.05 | P trend = 0.15 | |||
aAdjOR, ORs adjusted for age, smoking and alcohol consumption.
bHypomethylation.
Bold value indicts the association is statistically significant at the p value of 0.05