Table I.
Average polyp number in the intestinal tract of (BXH# x B6 Apc Min/+ )F1 offspring at 110–130 days of agea
Maternal parent of Apc Min/+ F1 offspringa , b | Average polyp number (±) | Colon polyp incidencec (%) | Number of mice | |
SI | Colon | |||
BXH2 | 51±25 | 0.31±0.53 | 29 | 35 |
BXH4 | 44±18 | 0.60±0.86 | 43 | 30 |
BXH8 | 28±14 | 0.34±0.67 | 24 | 38 |
BXH14d | 8±3 | 0.11±0.32 | 11 | 46 |
BXH22 | 37±21 | 0.40±0.61 | 33 | 48 |
B6cC3-1 | 57±27 | 0.70±0.88 | 47 | 30 |
B6 | 66±34 | 1.65±1.81 | 69 | 26 |
C3H.B6 | 10±05 | 0.31±0.59 | 25 | 32 |
aAll strains shown carry only B6 alleles (susceptible) from at least 136–141Mb at the Mom1 locus on Chromosome 4. Offspring analyzed were derived from four or more mating cages.
bLists the parental control and BXH RI test females crossed to B6 Apc Min/+ males to obtain F1 offspring from each group.
cColon polyp incidence was determined by dividing the number of F1 Apc Min/+ offspring with polyps in the proximal or distal colon by the total number the # mice.
dThe only strain to have one mouse with zero polyps in the intestinal tract was the BXH14 strain.