Table V.
Associations between candidate pathway genes and genetic admixture
| % Native American ancestry | 0–28 | 29–70 | 71–100 | Wald P Value (PACT)b | Interactionc P value | ||||||||||
| ORa | (95% CI) | OR | (95% CI) | OR | (95% CI) | 0–28 | 29–70 | 70–100 | |||||||
| IκBKB | |||||||||||||||
| rs3747811 | AA | 1.00 | 0.93 | (0.76, 1.15) | 0.72 | (0.55, 0.93) | 0.960 | 0.574 | 0.020 | 0.030 | |||||
| AT | 1.10 | (0.92, 1.30) | 1.01 | (0.84, 1.23) | 0.84 | (0.64, 1.12) | (0.056) | (0.032) | |||||||
| TT | 1.00 | (0.83, 1.21) | 0.99 | (0.78, 1.26) | 1.30 | (0.81, 2.08) | |||||||||
| rs5029748d | CC | 1.00 | 1.05 | (0.88, 1.25) | 1.21 | (0.82, 1.77) | 0.180 | 0.755 | 0.018 | 0.004 | |||||
| CA/AA | 1.11 | (0.97, 1.26) | 1.02 | (0.88, 1.17) | 0.78 | (0.64, 0.96) | (0.055) | (0.011) | |||||||
| rs10958713 | CC | 1.00 | 1.07 | (0.88, 1.30) | 1.11 | (0.74, 1.66) | 0.191 | 0.693 | 0.114 | 0.016 | |||||
| CT/TT | 1.10 | (0.96, 1.26) | 1.03 | (0.88, 1.19) | 0.81 | (0.65, 1.00) | (0.032) | ||||||||
| rs13278372 | CC/CA | 1.00 | 0.96 | (0.85, 1.08) | 0.77 | (0.64, 0.93) | 0.003 | 0.076 | 0.031 | <0.001 | |||||
| AA | 0.35 | (0.18, 0.69) | 1.82 | (0.87, 3.81) | 5.96 | (0.69, 51.83) | (0.009) | (0.059) | (<0.001) | ||||||
| mTOR | |||||||||||||||
| rs1057079e | AA | 1.00 | 0.94 | (0.81, 1.09) | 0.71 | (0.56, 0.89) | 0.518 | 0.323 | 0.027 | 0.035 | |||||
| AG | 0.93 | (0.81, 1.08) | 0.95 | (0.81, 1.11) | 0.79 | (0.61, 1.02) | (0.057) | (0.104) | |||||||
| GG | 1.00 | (0.78, 1.30) | 1.09 | (0.82, 1.43) | 1.32 | (0.80, 2.17) | |||||||||
| NFκB1 | |||||||||||||||
| rs4648090 | GG/GA | 1.00 | 0.96 | (0.86, 1.08) | 0.77 | (0.64, 0.94) | 0.007 | 0.541 | 0.980 | 0.080 | |||||
| AA | 0.48 | (0.29, 0.81) | 0.70 | (0.29, 1.66) | Too few to analyze | (0.050) | (0.879) | ||||||||
| PDK2 | |||||||||||||||
| rs4794096 | TT | 1.00 | 1.00 | (0.83, 1.19) | 0.93 | (0.71, 1.22) | 0.914 | 0.525 | 0.042 | 0.159 | |||||
| TG | 1.01 | (0.87, 1.17) | 0.94 | (0.80, 1.11) | 0.80 | (0.62, 1.02) | (0.042) | ||||||||
| GG | 1.01 | (0.83, 1.23) | 1.10 | (0.89, 1.36) | 0.62 | (0.44, 0.87) | |||||||||
| rs1063647 | TT | 1.00 | 1.00 | (0.82, 1.21) | 0.59 | (0.43, 0.81) | 0.537 | 0.248 | 0.024 | 0.144 | |||||
| TC | 0.93 | (0.80, 1.09) | 0.93 | (0.78, 1.10) | 0.77 | (0.60, 0.99) | (0.035) | ||||||||
| CC | 0.95 | (0.79, 1.15) | 0.88 | (0.72, 1.08) | 0.89 | (0.66, 1.19) | |||||||||
| PIK3CA | |||||||||||||||
| rs6443624 | CC | 1.00 | 1.07 | (0.93, 1.24) | 0.90 | (0.72, 1.12) | 0.277 | 0.080 | 0.027 | 0.013 | |||||
| CA/AA | 1.09 | (0.95, 1.24) | 0.95 | (0.82, 1.11) | 0.70 | (0.54, 0.91) | (0.333) | (0.121) | (0.091) | ||||||
| PIK3CB | |||||||||||||||
| rs10513055 | AA | 1.00 | 0.94 | (0.82, 1.08) | 0.77 | (0.63, 0.94) | 0.667 | 0.099 | 0.397 | 0.046 | |||||
| AC | 1.02 | (0.89, 1.18) | 1.04 | (0.87, 1.25) | 0.90 | (0.61, 1.33) | (0.176) | (0.092) | |||||||
| CC | 0.83 | (0.61, 1.13) | 1.34 | (0.83, 2.14) | 0.68 | (0.06, 7.60) | |||||||||
| PRKAA1 | |||||||||||||||
| rs10074991 | GG | 1.00 | 1.11 | (0.96, 1.29) | 0.97 | (0.77, 1.21) | 0.021 | 0.107 | 0.015 | <0.001 | |||||
| GA/AA | 1.17 | (1.03, 1.34) | 0.99 | (0.84, 1.15) | 0.71 | (0.55, 0.91) | (0.109) | (0.081) | (0.002) | ||||||
| rs3805486 | TT | 1.00 | 1.05 | (0.92, 1.20) | 0.86 | (0.70, 1.06) | 0.286 | 0.028 | 0.072 | 0.011 | |||||
| TC/CC | 1.09 | (0.94, 1.27) | 0.88 | (0.74, 1.04) | 0.67 | (0.49, 0.90) | (0.143) | (0.295) | (0.067) | ||||||
| PRKAG2 | |||||||||||||||
| rs10236110 | GG | 1.00 | 0.92 | (0.80, 1.06) | 0.70 | (0.57, 0.87) | 0.571 | 0.280 | 0.010 | 0.007 | |||||
| GA | 0.93 | (0.80, 1.06) | 1.03 | (0.86, 1.22) | 0.91 | (0.68, 1.22) | (0.118) | (0.086) | |||||||
| AA | 1.01 | (0.77, 1.32) | 0.98 | (0.67, 1.45) | 1.96 | (0.71, 5.41) | |||||||||
| PTEN | |||||||||||||||
| rs1903858f | TT | 1.00 | 0.91 | (0.77, 1.07) | 0.79 | (0.59, 1.04) | 0.006 | 0.558 | 0.332 | 0.468 | |||||
| TC/CC | 0.82 | (0.72, 0.94) | 0.86 | (0.75, 1.00) | 0.68 | (0.55, 0.84) | (0.021) | ||||||||
| RPS6KA2 | |||||||||||||||
| rs12199759 | AA | 1.00 | 1.08 | (0.94, 1.24) | 0.89 | (0.71, 1.12) | <0.001 | 0.443 | 0.533 | 0.001 | |||||
| AG | 1.22 | (1.05, 1.41) | 1.01 | (0.86, 1.19) | 0.81 | (0.63, 1.03) | (0.001) | (0.005) | |||||||
| rs3778405 | GG | 1.95 | (1.32, 288) | 1.01 | (0.73, 1.41) | 0.81 | (0.48, 1.36) | ||||||||
| AA | 1.00 | 0.95 | (0.83, 1.10) | 1.09 | (0.83, 1.43) | 0.981 | 0.358 | 0.001 | 0.009 | ||||||
| AG/GG | 1.04 | (0.88, 1.22) | 1.02 | (0.88, 1.17) | 0.71 | (0.57, 0.87) | (0.012) | (0.084) | |||||||
| rs3778401 | GG | 1.00 | 1.06 | (0.90, 1.26) | 0.72 | (0.58, 0.90) | 0.855 | 0.319 | <0.001 | 0.032 | |||||
| GA | 1.04 | (0.89, 1.21) | 0.87 | (0.73, 1.05) | 1.08 | (0.79, 1.48) | (0.002) | (0.193) | |||||||
| AA | 1.00 | (0.84, 1.20) | 1.16 | (0.87, 1.54) | 2.56 | (0.95, 6.86) | |||||||||
| TSC1 | |||||||||||||||
| rs2250057 | TT/TG | 1.00 | 1.00 | (0.88, 1.13) | 0.71 | (0.58, 0.87) | 0.204 | 0.074 | 0.015 | 0.090 | |||||
| GG | 0.90 | (0.74, 1.09) | 0.85 | (0.71, 1.02) | 0.95 | (0.72, 1.26) | (0.310) | (0.099) | (0.810) | ||||||
| rs7870151 | CC | 1.00 | 0.96 | (0.84, 1.09) | 0.82 | (0.67, 1.01) | 0.109 | 0.008 | 0.448 | ||||||
| CA | 1.06 | (0.91, 1.24) | 1.15 | (0.94, 1.41) | 0.71 | (0.50, 1.03) | (0.058) | 0.909 | |||||||
| AA | 1.49 | (0.98, 2.25) | 2.52 | (1.12, 5.68) | 0.90 | (0.20, 4.10) | |||||||||
aOdds ratios (OR) and 95% confidence intervals (CI) adjusted for age, study, BMI, parity, age at first birth, alcohol consumption and physical activity level.
bMain effect P value: multiple-comparison adjusted P value, PACT, shown in parenthesis.
cInteraction P value (gene × admixture); Holm’s adjusted P value for interaction, a step-down Bonferroni adjustment, shown in parenthesis.
drs55029748 has similar associations with rs10958713; their r2 is 0.61 for NHW and 0.82 for Hispanic women.
ers2295080 has similar associations as rs1057079; their r2 is 0.78 for NHW and 0.90 for Hispanic women.
frs2735343 has similar associations as rs1903858; their r2 is 0.93 for NHW and 0.95 for Hispanic women.