TABLE 2 .

Top Canonical Pathways Obtained Through Ingenuity in TMHF-Fed Mice

Pathway	p value	Ratio	Protein list
NRF2-mediated oxidative stress response	1.50E-17	16/192 (0.083)	AKR1A1, CAT, CBR1, EPHX1, FTH1, GCLC, GCLM, GSTA5, GSTM1, GSTM3, GSTM4, GSTM5, GSTO1, PPIB, PRDX1, TXN
Metabolism of xenobiotics by cytochrome P450	2.10E-17	14/197 (0.071)	AKR1A1, CYP2A6*, GSTA4, GSTA5, GSTM1, GSTM3, GSTM4, GSTM5, GSTO1, GSTT3, GSTZ1, UGT1A8*, UGT2B15, UGT2B17
Glutathione metabolism	7.53E-16	11/92 (0.120)	GCLC, GCLM, GSTA4, GSTA5, GSTM1, GSTM3, GSTM4, GSTM5, GSTO1, GSTT3, GSTZ1
Xenobiotic metabolism signaling	6.17E-12	14/296 (0.047)	ALDH1A1, CAT, CES1G, CES2A, GCLC, GSTA5, GSTM1, GSTM3, GSTM4, GSTM5, GSTO1, UGT1A8*, UGT2B15, UGT2B17

Note. Listed proteins are differentially expressed (fold change ≥ ±1.5) in TMHF-fed mice compared with control mice.

Boldface type indicates upregulated protein; regular type indicates downregulated protein.

*Protein includes other isoforms.