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Body mass index (BMI) (calculated as mean weight in kilograms divided by mean height in meters squared) (A) and adjusted change in BMI from baseline (B) (see text for further details). Data are plotted as the mean and 1 SE. Vertical dotted lines separate the study drug treatment (4–52 weeks) and post–study drug treatment (52–100 weeks) monitoring periods. Part A includes data for the run-in period (0–4 weeks). Metformin was given as metformin hydrochloride extended release.
