Table 1.

Type 2 Diabetes Mellitus Genome-wide Association Study Results^a,b

Chromosome	Position	Most Significant SNP	Meta P Value	Odds Ratio	In Gene	Closest Gene	eSNP Gene
10	114748339	rs7903146	3.26 × 10−13	0.72	TCF7L2
2	160922421	rs6718526	7.65 × 10−7	1.30	RBMS1		LY75
3	64711617	rs2371765	8.90 × 10−7	1.22		ADAMTS9
17	74333763	rs1531797	1.22 × 10−6	0.82	USP36		USP36
1	202547459	rs16853272	2.47 × 10−6	1.90	PLEKHA6
15	240948199	rs12148430	3.90 × 10−6	0.73		GABRB3
14	71978830	rs2283381	5.86 × 10−6	1.24	RGS6
20	60009590	rs17750066	5.98 × 10−6	0.64	TAF4
21	37158147	rs7282868	6.63 × 10−6	1.27	HLCS
17	62804441	rs8866	7.17 × 10−6	1.24	PITPNC1		PITPNC1
1	183539106	rs1208517	8.73 × 10−6	1.29	IVNS1ABP

Abbreviations: eSNP, expression-associated single nucleotide polymorphism; rs, reference single nucleotide polymorphism (identification number); SNP, single nucleotide polymorphism.

^a If multiple SNPs in linkage disequilibrium in the region were identified, the most significant SNP is noted, and the eSNP gene to any SNP in the region is noted. The P values reported are based on meta-analysis results from the Nurses' Health Study and the Health Professionals Follow-Up Study.

^b ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif, 9 gene; GABRB3, gamma-aminobutyric acid A receptor, beta 3 gene; HLCS, holocarboxylase synthetase gene; IVNS1ABP, influenza virus NS1A binding protein gene; LY75, lymphocyte antigen 75 gene; PITPNC1, phosphatidylinositol transfer protein, cytoplasmic 1 gene; PLEKHA6, pleckstrin homology domain containing, family A member 6 gene; RBMS1, RNA-binding motif, single-stranded interacting protein 1 gene; RGS6, regulator of G-protein signaling 6 gene; TAF4, TAF4 RNA polymerase II gene; TCF7L2, transcription factor 7-like 2 gene; USP36, ubiquitin-specific peptidase 36 gene.