Table 3.
Fat Cell Differentiation Human Gene Set and Accompanying eSNP Informationa
| Gene Symbolb | eSNP Tissue | eSNP rs id | GWAS P Value |
|---|---|---|---|
| CTSS | Omental adipose | rs10305724 | 0.05 |
| ADAM12 | Subcutaneous adipose | rs4962528 | 0.05 |
| PPARD | Subcutaneous adipose | rs6906237 | 0.06 |
| TAF8 | Omental adipose | rs9381135 | 0.06 |
| ADRB1 | Liver | rs7915120 | 0.07 |
| ERAP1 | Omental adipose | rs13160562 | 0.07 |
| HOXC4 | Subcutaneous adipose | rs11614913 | 0.11 |
| CCND1 | Subcutaneous adipose | rs12808959 | 0.13 |
| ADRB2 | Omental adipose | rs7729953 | 0.24 |
| BMPR1B | Omental adipose | rs1434546 | 0.26 |
| GPD1 | Liver | rs7532 | 0.29 |
| KLF7 | Liver | rs6732724 | 0.29 |
| CBY1 | Liver | rs4820345 | 0.34 |
| ENPP1 | Liver | rs9493120 | 0.34 |
| SMAD3 | Omental adipose | rs7166081 | 0.35 |
| WWTR1 | Omental adipose | rs10513355 | 0.38 |
| PPARG | Liver | rs1797912 | 0.39 |
| STEAP4 | Liver | rs3745178 | 0.43 |
| SOCS1 | Omental adipose | rs7197119 | 0.44 |
| UCP1 | Omental adipose | rs17005845 | 0.65 |
| MAP3K5 | Omental adipose | rs9373173 | 0.69 |
| LRRC8C | Omental adipose | rs2224652 | 0.74 |
| SFRP1 | Liver | rs6998193 | 0.79 |
| ADIG | |||
| BMP7 | |||
| CEBPA | |||
| CEBPB | |||
| HMGA2 | |||
| IL11 | |||
| INSR | |||
| JARID1A | |||
| KLF6 | |||
| MED1 | |||
| NFATC4 | |||
| NR5A2 | |||
| PPARGC1A | |||
| RUNX1T1 | |||
| SAFB | |||
| TCF7L2 |
Abbreviations: dbSNP, National Institutes of Health single nucleotide polymorphism database; eSNP, expression-associated single nucleotide polymorphism; GWAS, genome-wide association studies; rs id, reference single nucleotide polymorphism identifier; SSEA, single nucleotide polymorphism set enrichment analysis.
a Genes represented by an eSNP in the SSEA are noted by tissue and dbSNP rs id information.
b ADAM12, ADAM metallopeptidase domain 12 gene; ADIG, adipogenin gene; ADRB1, adrenergic, beta-1-receptor gene; ADRB2, adrenergic, beta-2-receptor; BMP7, bone morphogenetic protein 7 gene; BMPR1B, bone morphogenetic protein receptor, type IB gene; CBY1, chibby homolog 1 gene; CCND1, cyclin D1 gene; CEBPA, CCAAT/enhancer binding protein, alpha gene; CEBPB, CCAAT/enhancer binding protein, beta gene; CTSS, cathepsin S gene; ENPP1, ectonucleotide pyrophosphatase/phosphodiesterase 1 gene; ERAP1, endoplasmic reticulum aminopeptidase 1 gene; GPD1, glycerol-3-phosphate dehydrogenase 1 gene; HMGA2, high mobility group AT-hook 2 gene; HOXC4, homeobox C4 gene; IL11, interleukin 11 gene; INSR, insulin receptor gene; JARID1A, lysine-specific demethylase 5A gene; KLF6, Kruppel-like factor 6 gene; KLF7, Kruppel-like factor 7 gene; LRRC8C, leucine-rich repeat containing 8 family, member C gene; MAP3K5, mitogen-activated protein kinase kinase kinase 5 gene; MED1, mediator complex subunit 1 gene; NFATC4, nuclear factor of activated T-cells calcineurin-dependent 4 gene; NR5A2, nuclear receptor subfamily 5, group A, member 2 gene; PPARD, peroxisome proliferator-activated receptor delta gene; PPARG, peroxisome proliferator-activated receptor gamma gene; PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha gene; RUNX1T1, runt-related transcription factor 1 gene; translocated to 1, gene; SAFB, scaffold attachment factor B gene; SFRP1, secreted frizzled-related protein 1 gene; SMAD3, SMAD family member 3 gene; SOCS1, suppressor of cytokine signaling 1 gene; STEAP4, STEAP family member 4 gene; TAF8, TAF8 RNA polymerase II gene; TCF7L2, transcription factor 7-like 2 gene; UCP1, uncoupling protein 1 gene; WWTR1, WW domain containing transcription regulator 1 gene.