Figure 2.

Characteristics of T2DM development and progression. A) Overview of changes in blood glucose, fasting serum insulin and insulin resistance during the initiation and progression of T2DM. Modified from [31]. B) Disposition index indicating the relationship between insulin sensitivity and insulin secretion in β-cells of normal individuals and T2DM patients. C) Β-cell loss during disease progression in T2DM. The graph is based on findings by Butler et al. and Holman et al.[6,34]. (IFG = Impaired fasting glucose).