Table 2.
Association of VEGF-C and VEGF-D expression with P-LVD and I-LVD in breast cancer
| Cases (N) | I- LVD (mean ± SD) | P-valuea | P-LVD (mean ± SD) | P-valuea | ||
|---|---|---|---|---|---|---|
| VEGF-C |
Negative |
11 |
5.17 ± 2.23 |
0.96 |
5.77 ± 2.47 |
<0.001 |
| |
+ |
17 |
5.72 ± 2.02 |
|
7.74 ± 2.75 |
|
| |
++ |
26 |
5.41 ± 1.94 |
|
9.03 ± 2.88 |
|
| |
+++ |
12 |
5.46 ± 2.19 |
|
10.82 ± 3.12 |
|
| |
++++ |
7 |
5.59 ± 2.44 |
|
11.53 ± 3.26 |
|
| VEGF-D |
Negative |
18 |
5.19 ± 2.25 |
0.88 |
6.78 ± 2.86 |
0.005 |
| |
+ |
20 |
5.35 ± 1.81 |
|
8.28 ± 2.61 |
|
| |
++ |
21 |
5.53 ± 1.86 |
|
9.96 ± 3.42 |
|
| |
+++ |
9 |
5.81 ± 2.53 |
|
10.13 ± 3.36 |
|
| ++++ | 5 | 6.16 ± 2.47 | 11.66 ± 3.06 |
I-LVD, intratumoral lymphatic vessel density; P-LVD, peritumoral lymphatic vessel density; VEGF-C/D, vascular endothelial growth factor C /D; aOne-way analysis of variance.