Table 1. Representation of predicted and validated miRNAs targeting Eph receptors and ephrin ligands.

Ephrin/ Eph receptor	Position: 5′-3′ of 3′-UTR	Predicted miRNA binding
EphrinA1	235–241	miR-9 miR-22385 miR-122, miR-451 and miR-2786
EphrinA2	NA	NA miR-122, miR-451 and miR-2786
EphrinA3	467–173, 474–480, 791–797	miR-30, miR-130, miR-153 miR-21087
EphrinA4	NA*	NA*
EphrinA5	NA	NA
EphrinA6	NA*	NA*
EphrinA7	NA*	NA*
EphrinB1	195–201	miR-124 77
EphrinB2	1880–1886, 2871–2877, 2952–2958, 3078–3084,	miR-153, miR-182, miR-200, miR-1 and miR-206,
EphrinB3	901–907	miR-124
EphA1	106–112	miR-29
EphA2	24–30 729–735	miR-2689 miR-141 and miR-200
EphA3	NA*	NA*
EphA4	36–42, 48–54	let-7, miR-17
EphA5	NA*	NA*
EphA6	NA*	NA*
EphA7	776–782, 1815–1821, 1817–1823	miR-137, miR-133, miR-9
EphA8	550–556, 1162–1168, 1322–1328, 1323–1329	miR-138, miR-218, miR-25/32/92, miR-137
EphA9	NA	NA
EphB1	NA*	NA*
EphB2	1403–1409	miR-128
EphB3	775–781	miR-137
EphB4	107–113, 317–323, 318–324	miR-17/93/106, miR-133, miR-9
EphB5	NA	NA
EphB6	NA*	NA*

Predictions of the 5′-3′ mRNA sequence position and corresponding miRNA are assessed by TargetScan 5.1. Sites shown have a high probability of preferential conservation between human, rhesus, chimpanzee and mouse. Potential miRNAs derived from experimental evidence are italicized. Validated miRNAs are in bold. NA, Eph receptor or ephrin ligand gene not in TargetScan database; NA*, no highly conserved sites.