Table 1. The main subunits of the SWI/SNF complex and their function (based on refs. 2 and 5).
| Official gene name | Alternative name | Putative function |
|---|---|---|
| SMARCA2 or SMARCA4 |
BRG1 hBRM |
Performs ATP hydrolysis, binds acetylated histones, regulates transcription and acts as a tumor suppressor.2,5 |
| ARID1A or ARID1B or ARID2 |
BAF250a BAF250b BAF200 |
Performs DNA target recognition, involved in protein-protein interactions, regulates transcription and acts as a tumor suppressor.2,5 |
| SMARCB1 |
BAF47/hSNF5 |
Regulates transcription, acts as a tumor suppressor.2,5 |
| SMARCE1 |
BAF57 |
Regulates transcription,40 acts as a tumor suppressor32 |
| SMARCC1 and/or SMARCC2 |
BAF155 BAF170 |
Stabilizes the SWI/SNF complex,41 acts as a tumor suppressor42 |
| SMARCD1 or SMARCD2 or SMARCD3 |
BAF60a BAF60b BAF60c |
Acts as a tumor suppressor21 |
There are many different combinations of subunits possible to form the SWI/SNF complex. The first column indicates if the subunits are mutually exclusive (such as SMARCA2/SMARCA4) or can occur together in the complex (such as SMARCC1/SMARCC2).