Figure 5. HP1a binds independently of POF and Setdb1 to promoters.

(A) HP1a profiles in five illustrative regions of the 4^th chromosome in wild type, Pof and Setdb1 backgrounds. Numbers along the x-axis denote chromosomal positions along the chromosomes in Mb. The y-axis shows the ChIP enrichment in log₂ ratios. Genes expressed from left to right and vice versa are shown above and below the horizontal lines, respectively. The HP1a methylation-independent promoter peaks are indicated by yellow boxes. (B) Average metagene profiles of HP1a enrichments on the 4^th chromosome in wild type (solid black), Pof (solid gray) and Setdb1 (dashed gray) backgrounds.