Table 6.
Incremental cost-effectiveness ratios and distribution of the joint cost-effect pairs in the cost-effectiveness planes of the internet group resulting from the main analyses and the sensitivity analyses
|
Analysis |
Sample size per group |
ΔC (95% CI) |
ΔE (95% CI) |
|
Distribution in CE plane (%) |
||||
|---|---|---|---|---|---|---|---|---|---|
| Control | Internet | Weight loss (kg) | ICER | NEb | SEc | SWd | NWe | ||
| Main |
448 |
450 |
14 (−790; 867) |
0.9 (−0.1; 1.9) |
16 |
50 |
48 |
1 |
1 |
| Complete cases |
134 |
129 |
-82 (-838 to 633) |
1.3* (0.3; 2.4) |
−62 |
41 |
58 |
0 |
0 |
| Company perspective |
448 |
450 |
−149 (−858; 618) |
0.9 (−0.1; 1.9) |
−171 |
33 |
65 |
2 |
1 |
| |
|
|
|
QALY |
ICUR |
|
|
|
|
| Main |
448 |
450 |
14 (−774; 887) |
0.01 (−0.01; 0.04) |
1337 |
35 |
47 |
5 |
14 |
| Complete cases |
120 |
125 |
−307 (−1179; 315) |
0.02 (−0.02; 0.06) |
−27,908 |
17 |
71 |
8 |
5 |
| Company perspective |
448 |
450 |
−149 (−858; 618) |
0.01 (−0.01; 0.04) |
−14,181 |
23 |
58 |
8 |
11 |
| UK tariff | 448 | 450 | 14 (−774; 887) | 0.02 (−0.02;0.06) | 702 | 41 | 47 | 4 | 9 |
a In the analysis ΔC= mean difference in total costs, ΔE= mean difference in outcome, ICER (ICUR) =incremental cost-effectiveness (utility) ratio calculated as ΔC/ΔE. In the main analysis missing data were multiply imputed. The complete cases analysis was restricted to participants with complete cost and effect data. b Northeast quadrant of the CE-plane: the intervention is more effective and more costly than self-help brochures. Southeast quadrant of the CE-plane: the intervention is more effective and less costly than self-help brochures. d Southwest quadrant of the CE-plane: the intervention is less effective and less costly than self-help brochures. e Northwest quadrant of the CE-plane: the intervention is less effective and more costly than self-help brochures. *p=0.01.