Table 3.
Comparison of areas under the ROC curves (95% CI) for potential markers of insulin resistance (HOMA-IR ≥2.5) of subjects categorized by body mass index
|
Body mass index characteristics |
AUC (95% CI) |
|||||
|---|---|---|---|---|---|---|
| |
Total |
P-value |
Non-obese |
P-value |
Overweight |
P-value |
| All N = 1,342 | <25.0 kg/m2 N = 998 | ≥25.0 kg/m2 N = 344 | ||||
| Triglycerides (mg/dL) |
0.69 (0.65-0.73) |
<0.001 |
0.66 (0.59-0.73) |
<0.001 |
0.65 (0.58-0.71) |
<0.001 |
| High sensitivity CRP (mg/dL) |
0.68 (0.64-0.72) |
<0.001 |
0.61 (0.55-0.68) |
0.003 |
0.63 (0.57-0.70) |
<0.001 |
| Serum HMW adiponectin (μg/mL) |
0.32 (0.28-0.36) |
<0.001 |
0.32 (0.25-0.39) |
<0.001 |
0.40 (0.33-0.46) |
0.003 |
| GGT (IU/L) |
0.63 (0.58-0.67) |
<0.001 |
0.61 (0.54-0.67) |
0.005 |
0.54 (0.48-0.61) |
0.211 |
| ALT (IU/L) |
0.69 (0.64-0.73) |
<0.001 |
0.62 (0.55-0.69) |
0.002 |
0.66 (0.59-0.72) |
<0.001 |
| AST (IU/L) |
0.56 (0.51-0.61) |
0.013 |
0.49 (0.41-0.57) |
0.818 |
0.59 (0.52-0.66) |
0.007 |
| ALT/AST ratio | 0.74 (0.70-0.78) | <0.001 | 0.70 (0.63-0.77) | <0.001 | 0.66 (0.59-0.72) | <0.001 |
ROC, receiver operating characteristics; CI, confidence interval; AUC, area under ROC curve. Data for triglycerides, high sensitivity CRP, serum HMW adiponectin, GGT, ALT, AST, and ALT/AST ratio were skewed and log-transformed for analysis.