Table 6.
Association between ALT/AST ratio and insulin resistance (HOMA-IR ≥2.5) and HOMA-IR within selected subgroups
|
Stratified subgroups |
N |
HOMA-IR ≥2.5,% |
ALT/AST ratio |
||
|---|---|---|---|---|---|
| ROC curves AUC (95%CI) | BMI-adjusted β (P-value) | Multivariate-adjusted β (P-value) | |||
| Men Body mass index (kg/m2) |
|
|
|
|
|
| Total |
587 |
66 (11.2) |
0.75 (0.68-0.81 |
0.253 (<0.001) |
0.104 (0.016) |
| <22.0 |
202 |
7 (3.5) |
0.67 (0.44-0.89) |
0.257 (<0.001) |
0.141 (0.051) |
| 22.0-25.0 |
225 |
19 (8.4) |
0.64 (0.51-0.77) |
0.317 (<0.001) |
0.166 (0.030) |
| <25.0 |
427 |
26 (6.1) |
0.67 (0.56-0.77) |
0.274 (<0.001) |
0.143 (0.004) |
| ≥25.0 |
160 |
40 (25.0) |
0.73 (0.63-0.82) |
0.215 (0.005) |
0.052 (0.600) |
| Women Body mass index (kg/m2) |
|
|
|
|
|
| Total |
755 |
101 (13.4) |
0.75 (0.70-0.81) |
0.197 (<0.001) |
0.104 (0.002) |
| <22.0 |
308 |
10 (3.2) |
0.74 (0.62-0.87) |
0.149 (0.008) |
0.055 (0.334) |
| 22.0-25.0 |
263 |
26 (9.9) |
0.71 (0.60-0.82) |
0.250 (<0.001) |
0.136 (0.039) |
| <25.0 |
571 |
36 (6.3) |
0.74 (0.65-0.82) |
0.194 (<0.001) |
0.092 (0.026) |
| ≥25.0 | 184 | 65 (35.3) | 0.68 (0.60-0.76) | 0.231 (0.001) | 0.176 (0.019) |
Multivariate-adjusted for confounding factors in Table 4.