Table 4.
Subgroup analysis of the intervention effect on the percentage of days adherence to prescribed medication
| Sub-group variable | Sub-group category (L = Low or H = High) | N per sub group | Intervention arm | Standard care arm | Intervention- Control (SE)* | Difference (H-L) (95% C.I.) | P interaction |
|---|---|---|---|---|---|---|---|
| HbA1c % (mmol/mol) |
7.5 – 7.9 (58-63) |
85 |
80.4 (24.5) |
62.6 (34.2) |
17.7 (6.4) |
|
|
| |
8.0 - 12.4 (64-112) |
108 |
74.8 (27.7) |
72.8 (27.8) |
2.0 (5.3) |
-15.8 (-32.9, 1.2) |
0.07 |
| Age (years) |
37 – 64 |
94 |
75.0 (25.61) |
72.3 (27.3) |
2.7 (5.6) |
|
|
| |
65 and over |
100 |
80.0 (27.1) |
66.4 (33.2) |
13.5 (6.0) |
10.8 (-5.4, 27.2) |
0.19 |
| Total number of medications |
0 – 5 |
89 |
80.2 (23.3) |
73.0 (27.0) |
7.2 (5.3) |
|
|
| |
6 and over |
105 |
75.1 (28.5) |
65 .2 (33.7) |
10.0 (6.1) |
2.8 (-13.5, 19.1) |
0.74 |
| Self reported adherence at baseline |
0-23 |
102 |
75.0 (26.4) |
70.9 (27.2) |
4.1 (5.5) |
|
|
| |
24 or 25 |
70 |
85.9 (21.3) |
68.0 (33.9) |
17.9 (6.8) |
13.8 (-3.2, 30.0) |
0.11 |
| Prior randomisation to medication monitoring device |
No |
102 |
76.6 (28.7) |
71.0 (29.3) |
5.6 (5.8) |
|
|
| |
Yes |
92 |
78.2 (23.7) |
66.65 (32.6) |
11.6 (5.9) |
6.0 (-10.5, 22.7) |
0.48 |
| Gender |
Male |
127 |
77.0 (28.3) |
66.4 (31.5) |
10.6 (5.3) |
|
|
| Female | 67 | 78.0 (22.9) | 74.8 (28.8) | 3.3 (6.4) | -7.3 (-24.3, 9.6) | 0.39 |
Effect estimates, confidence intervals and p-values from non-parametric bootstrap percentile method (50,000 replications).
* Estimated intervention effects are positive within each subgroup.