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Effects of metformin on the normal growth of glioblastoma multiforme (GBM) cells. Cell growth in the presence or absence of 0–16 mM concentrations of metformin was assessed as described in Materials and methods. The number of cells in untreated cultures is taken as 100%. Differences between untreated and treated cells (± SE) were calculated as described in Materials and methods; *p≤0.05; **p≤0.01.
