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. 2012 Nov 15;7(11):e50013. doi: 10.1371/journal.pone.0050013

Figure 1. Global analysis of ChIP-seq and microarray data.

Figure 1

(A) Venn diagrams of RXRα-bound genes (III+IV+V), hepatic genes (I+II+III+IV), and RXRα-dependent genes (II+III). RXRα binding location for (B) RXRα-dependent, (C) RXRα-independent hepatic expressed, and (D) non-hepatic expressed genes. In gene: peak summit located within the coding region; Promoter: peak summit located within −2 kb ∼0 bp to the transcription start site (TSS); Upstream: peak summit located within -100 kb∼−2 kb to the TSS; Downstream: peak summit located within 0 bp ∼100 kb to 3′ end of the gene; Intergenic: peak summit located outside the above mentioned regions. Red circle: RXRα-dependent genes; Blue circle: hepatic genes; Yellow circle: RXRα-bound genes. I: RXRα-independent genes and lack of RXRα binding; II: RXRα-dependent genes but lack of RXRα binding; III: RXRα-dependent genes that have RXRα binding; IV: RXRα-independent genes that have RXRα binding; V: non-hepatic genes that have RXRα binding.