Figure 3. Etanercept treatment significantly attenuates plasma TNF-α, IL-6 and CD40L in mice with AOM-induced ALF.

Etanercept was administered 30 min before AOM. Plasma TNF-α (A), IL-6 (B) and CD40L (C) were quantified by ELISA. Data represent mean ± SEM of n = 12 animals in each group for IL-6, and n = 6 for TNF-α and CD40L. **p<0.001 vs. Saline; †p<0.05 vs. AOM; ††p<0.001 vs. AOM.